GARD: a genetic algorithm for recombination detection

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GARD: a genetic algorithm for recombination detection

MOTIVATION Phylogenetic and evolutionary inference can be severely misled if recombination is not accounted for, hence screening for it should be an essential component of nearly every comparative study. The evolution of recombinant sequences can not be properly explained by a single phylogenetic tree, but several phylogenies may be used to correctly model the evolution of non-recombinant fragm...

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Automated phylogenetic detection of recombination using a genetic algorithm.

The evolution of homologous sequences affected by recombination or gene conversion cannot be adequately explained by a single phylogenetic tree. Many tree-based methods for sequence analysis, for example, those used for detecting sites evolving nonneutrally, have been shown to fail if such phylogenetic incongruity is ignored. However, it may be possible to propose several phylogenies that can c...

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ژورنال

عنوان ژورنال: Bioinformatics

سال: 2006

ISSN: 1367-4803,1460-2059

DOI: 10.1093/bioinformatics/btl474